• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to a body monitoring device (1), comprising at least one sensor (24) of a physical quantity of interstitial fluid and data processing means (11) configured to process measurements acquired by said one sensor ( 24), characterized in that it further comprises a fluidic circuit (20) in one direction on which are arranged successively transcutaneous sampling means (25) interstitial fluid, said sensor (24), an absorbent foam (23) and a pump (21), said pump being controlled by the data processing means (11). The present invention also relates to a removable capsule for such a device.
    公开号:FR3059886A1
    申请号:FR1662200
    申请日:2016-12-09
    公开日:2018-06-15
    发明作者:Luc Pierart
    申请人:Pk Paris；
    IPC主号:
    专利说明:

    GENERAL TECHNICAL AREA
    The present invention relates to microfluidics. More specifically, it relates to a body monitoring system via interstitial fluid analysis.
    STATE OF THE ART
    Certain pathologies such as diabetes require daily monitoring of biochemical parameters of the human body, i.e. concentrations of certain compounds (blood sugar in the example of glucose).
    For this, it is common to prick a point on the skin so as to make a drop of blood pearl, and to analyze this drop either reactively (for example with a strip) or electronically (for example by less than one analytical sensor), so as to estimate the target parameter (s).
    Today we know much less invasive advanced systems that simply analyze the interstitial fluid, that is to say the fluid that fills the space between blood capillaries and cells. It indeed has an ionic composition close to that of blood plasma.
    These advanced systems thus make it possible to monitor the desired biochemical parameters transcutaneously, that is to say without the need to regularly pierce the skin and take a sample.
    In particular, a device worn on the wrist called GlucoWatch has been proposed, implementing a phenomenon called iontophoresis (or iontophoresis) in which an electric field makes it possible to "attract" the interstitial fluid through the skin to a sensor on the device wall. However, this concept was quickly abandoned because only 6% of patients endured the pain of electrical extraction. In addition, the measurement results were unreliable.
    Transcutaneous probes have been proposed alternately, taking the form of a self-adhesive patch plating a "needle sensor" just under the skin, so as to put the sensor in permanent fluid communication with the interstitial fluid, for continuous monitoring.
    Some of these transcutaneous patch type probes include wireless communications means making it possible to trace the measurements on the interstitial fluid, for example to a mobile terminal, for storage and processing (verification of thresholds and variations, production of statistics, triggering of alerts if necessary, etc.). Examples include sugarBEAT ™ or FreeStyle Libre systems.
    Such systems are satisfactory (the patches are much more reliable and less painful than iontophoresis devices), but prove to be restrictive and expensive because of the single-use patch which must be changed regularly. In addition, the patches tend to peel off, tear off when you change your clothes or make sudden movements, and are very visible: the wearer can be stigmatized as "sick".
    It would be desirable to have an alternative portable electronic system which avoids the use of patches, painlessly, and without there being the slightest hygienic risk.
    PRESENTATION OF THE INVENTION
    The present invention relates to a body monitoring device, comprising a one-way fluid circuit on which are arranged transcutaneous interstitial fluid withdrawal means, at least one sensor for a physical quantity of interstitial fluid, an absorbent foam and a pump, and data processing means configured to process measurements acquired by said sensor and control said pump;
    characterized in that it includes:
    a box in which the data processing means and the pump are arranged, and
    - A capsule in which the sensor, the foam and the transcutaneous sampling means are arranged;
    the capsule being configured to engage with the housing in a removable manner.
    According to other advantageous and non-limiting characteristics:
    • the housing and the capsule include electrical connectors and fluidic connectors, configured so that when the capsule is engaged with the housing, said electrical connectors ensure a connection between the data processing means and the sensor, and said fluid connectors ensure that the fluid circuit extends in a sealed manner both in the case and the capsule;
    • a first fluid connection of the housing is a needle, and a first fluid connection of the capsule is a tube having a cover pierced by said needle at the first engagement of the capsule with the housing;
    • the capsule has a substantially cylindrical shape relative to a given axis and engages with the housing in a translational movement along said axis and / or rotation around said axis by means of a tool, said tube and needle forming first fluid connections coinciding with said axis so that the engagement of the capsule with the case causes the insertion of the needle into the tube;
    • the capsule has a movable part comprising said transcutaneous sampling means intended to come into prolonged contact with the skin;
    • the capsule comprises a protruding ring made of a deformable material around the transcutaneous sampling means;
    • the box has a user interface;
    • the device includes an opening towards the outside at the level of the absorbent foam allowing the evaporation of the stored interstitial liquid;
    • the transcutaneous sampling means are micro-needles;
    • the case comprises means for attaching to the reusable body, configured to maintain the means for transcutaneous sampling in contact with the skin;
    • said reusable body attachment means consist of a strap or bracelet configured to surround a member;
    • the transcutaneous sampling means, the sensor, the pump and the absorbent foam are successively arranged on the fluid circuit, so that the liquid withdrawn leaves the capsule then returns to it.
    The invention also proposes, according to a second aspect of the invention, the capsule for a device according to the first aspect, comprising the means for transcutaneous sampling of interstitial liquid, the sensor, and the absorbent foam.
    PRESENTATION OF THE FIGURES
    Other characteristics and advantages of the present invention will appear on reading the following description of a preferred embodiment. This description will be given with reference to the appended drawings in which:
    - Figure 1 is a general diagram of the device according to the invention;
    - Figures 2a and 2b are two views of a preferred embodiment of a device according to the invention;
    - Figure 2c is an exploded view of the preferred embodiment of a device according to the invention;
    - Figure 3 shows a capsule of the preferred embodiment of a device according to the invention;
    - Figures 4a and 4b show a detail of a fluid element of the capsule of the preferred embodiment of a device according to the invention.
    DETAILED DESCRIPTION
    General architecture
    Referring to Figure 1, which shows a general diagram, the present invention relates to an electronic device 1 for body monitoring.
    By bodily monitoring is meant the verification of biochemical constants of a person carrying the device 1, typically the concentration of a protein, a hormone, a marker, oxygen, nutrients, etc., in the interstitial fluid of the person. We will cite the example of blood sugar. The person skilled in the art will be able to monitor other physical physical quantities such as temperature, hydration, etc. if necessary.
    The device 1 thus comprises at least one sensor 24 of a physical quantity of the interstitial liquid, in particular a sensor of “biochemical” nature, that is to say allowing the analysis of the interstitial liquid in particular by detecting a compound for example by with several electrodes in contact with the interstitial liquid, and advantageously at least one second sensor such as a temperature sensor making it possible to adjust the analysis of the interstitial liquid sampled (taking into account the viscosity of the fluid as a function of the temperature).
    It also includes data processing means 11 (in particular a processor or a microcontroller) configured to process measurements acquired by the sensor 24, and where appropriate data storage means 12 (in particular a memory, in particular of the type flash, and / or the memory of the microcontroller) allowing for example to store these measurements, and / or a date of the first use of each sensor 24 to calculate an expiration date of the sensor (s) 24 (the biochemical sensors have a duration of limited life). It also includes a battery for the electrical supply of the components, advantageously rechargeable, for example via port 10 (which it is understood that it can also be used to connect the device 1 for example to a computer to download the acquired data and / or processed).
    Preferably, the device 1 can comprise wireless connection means (in particular of the WiFi type, but also Bluetooth, or even
    3G / 4G) for connection to a network, in particular the Internet, and a user interface such as a screen, possibly touch screen to display the monitoring results to the user.
    It will be understood that a person skilled in the art knows algorithms for processing sensor measurements 24 and associated interfaces, and will be able to implement them in the present device 1, which, as will be seen, is essentially distinguished by a particular structure of a fluidic network. .
    Fluid circuit
    The present device 1 comprises a one-way fluid circuit 20 on which are disposed transcutaneous sampling means 25 of interstitial liquid, said sensor 24, an absorbent foam 23 and a pump 21, said pump being controlled by the data processing means. 11.
    Said transcutaneous interstitial fluid sampling means 25 advantageously consist of a network of micro-needles in contact with the skin when the device 1 is placed on the body of a person (see how below). Microneedles allow painless removal of interstitial fluid from the dermis without bleeding.
    Preferably, said transcutaneous sampling means 25 comprise between four and sixteen micro-needles (in particular four, nine or sixteen in the form of a square), substantially pyramidal, with tips of a height between 0.3mm and 0.8mm, each with a hole with a diameter between 0.04 and 0.22mm. Each of these advantageous characteristics of micro-needles can be taken separately or in combination with the others.
    The pump 21 is preferably a piezoelectric micro-pump allowing the suction thanks to a membrane vibration system. When it works (on command of data processing means
    11) it will cause the transcutaneous extraction (through the epidermis) of interstitial liquid from the body (the dermis under the epidermis), its circulation through circuit 20 to the sensor 24 which will analyze it, then its arrival at the absorbent foam 23 thus allowing it to be stored and evacuated by evaporation (the foam is advantageously in exchange with the atmosphere, in particular through a fabric porous to gases, so as to allow this evaporation, but advantageously liquid-tight (for example based on polytetrafluoroethylene) so as to avoid the penetration of liquids such as sweat from the outside). The circulation is only in one direction, which means that the withdrawal means 25 are the only fluid inlet, and the foam 23 is the only outlet. There is no cycle.
    Capsule
    Unlike known systems, the device 1 is integral. This means that there is not a main module such as a mobile terminal connected wirelessly to a bulky and expensive secondary module (due to the need to equip it with a battery, wireless communication means , etc.) taking the form of a patch stuck to the skin. The device 1 is thus autonomous.
    To be used, it is either pressed against the skin if necessary by the user for a few seconds (it is in this case devoid of any means of attachment to the body), or directly worn on the body, in particular on a limb, and preferably on the wrist. The device 1 then takes for example the shape of a watch, with a face F against the skin of the arm, and an opposite face accommodating for example a screen.
    As such, it advantageously comprises means for attaching to the reusable body, typically consisting of a strap or bracelet configured to surround the member (and not a sticky element), in particular a watch strap. "Reusable" means here as opposed to "single use" as was the case with patches, which cannot be reused after being peeled off and must be discarded. A bracelet can be opened and closed many times.
    The device 1 is configured so that when it is placed on the skin (ie when the attachment means fix it to the body) the transcutaneous sampling means 25 are held against the skin (or at least in the immediate vicinity) to allow the sample.
    In all cases, the device 1 contains two subsets:
    - a box 2 in which are arranged at least the data processing means 11 and the pump 21 (as well as the main components such as the battery, the memory, the possible user interface, etc.);
    - A capsule 3 in which are arranged the sensor 24, the foam 23 (as preferably explained in exchange with the atmosphere to promote the evaporation of the fluid and thus limit its stagnation, if necessary via a first window 26a through the capsule 3 and a second window 26b through the housing 2) and the transcutaneous sampling means 25, the capsule 3 being configured to engage with the housing 2 in a removable manner. It will be understood that the capsule 3 does not include a pump (this is in the housing 2), and therefore it only receives a "passive" portion of the circuit 20. The capsule 3 preferably engages in a cavity C of the case 2 located on its face F intended to be in contact with the skin.
    In other words, and as can be seen in FIG. 1 and FIGS. 2a2c which represent a preferred embodiment, the device 1 remains composed of two modules 2, 3 but the latter are not physically separated as could be be the case in the prior art and are even in direct, fluidic and electrical connection.
    The case 2 and the capsule 3 comprise for this electrical connectors 12a, 12b (contacts) and fluid connectors 22a, 22b, 22c, 22d (we will see their structure below) which can be seen particularly in FIGS. 2a and 2b, configured so that when the capsule 3 is engaged with the housing 2, said electrical connectors 12a, 12b provide a connection between the data processing means 11 and the sensor 24 (for raising the measurement data), and said fluid connectors 22a, 22b, 22c, 22d ensure that the fluid circuit 10 extends in a sealed manner both in the housing 2 and the capsule 3 (so that the suction power of the pump 21 is not altered).
    The capsule 3 thus constitutes an interchangeable sub-assembly of the device 1 which can be chosen according to the type of monitoring desired. Indeed, insofar as the capsule contains the sensor (s) 24, changing the capsule makes it possible to change sensors 24 if they are at the end of their life or if one wishes to change the physical quantity measured, in a simple manipulation , fast and safe, without having to throw away other parts (especially the limp
    2). It is noted in this respect that the capsule 3 very effectively preserves the sensors 24, and needs to be changed less often than a patch (the same capsule can be used for a month).
    And since capsule 3 does not contain a pump or advanced electronic equipment such as a battery or wireless communication means, it is significantly cheaper than a patch.
    The present device is therefore much more practical than the systems known from the prior art, but above all much cheaper to use, without there being the slightest hygienic risk, and without pain due to the insertion of a needle or strong electricity.
    In a first embodiment, the transcutaneous sampling means 25 of interstitial liquid, the sensor or sensors 24, the absorbent foam 23 and the pump 21 are successively arranged on the fluid circuit 20.
    Thus no fluid can be sucked into the pump 21 after its absorption by the foam 23 (insofar as the pump 21 is downstream of the foam 23 according to the circuit 20), which makes it possible to preserve it, but above all d '' prevent contamination of the housing 2.
    Furthermore, the capsule 3 is the only part of the device 1 which can be in contact with interstitial liquid, since it contains the absorbent foam 23 (beyond which the fluid withdrawn cannot rise). Thus, the removable capsule prevents contamination of the housing 2 and makes it possible to be able to replace the capsule 3 at the end of the life of the sensors 24 or change the type of capsule 3 in a simple, rapid and safe handling, without having to throw away other parts.
    ίο
    In a second embodiment, corresponding more precisely to the figures, the transcutaneous sampling means 25, the sensor 24, the pump 21 and the absorbent foam 23 are successively arranged on the fluid circuit 20, so that the liquid withdrawn leaves the capsule 3 then returns to it.
    This configuration does not prevent the entry of fluid into the housing 2, but allows optimization of the suction (the pump works on liquid and not air), which makes it smaller and less powerful, for a lower cost and electricity consumption.
    In this embodiment, it is necessary that there is a set of first fluidic connections 22a, 22b (for the outlet of the liquid from the capsule, corresponding to the portion of the circuit 20 upstream of the pump 21) and a set second fluid connectors 22c, 22d (for the return of the liquid in the capsule, corresponding to the portion of the circuit 20 downstream of the pump 21, up to the foam 23).
    We will see later that this mode also allows better preservation of the sensors 24.
    Capsule change
    With particular reference to FIGS. 2a and 2b, in the preferred embodiment shown, the first fluid connection 22a of the housing 2 is a needle, and the first fluid connection 22b of the capsule 3 is a tube.
    This tube advantageously has a cover pierced by said needle at the first engagement of the capsule 3 with the case 2. This allows on the one hand to have the capsule 3 (and in particular the portion of the circuit 20 containing the sensor 24 and s' extending between the sampling means 25 and the first connector 22b) sealed before its first use so as to prevent any contamination thereof, to preserve the sensor 24 (which has a limited lifespan), and on the other hand to guarantee the tightness of the circuit 20 between the box 2 and the capsule 3. Note that it is not necessary for the second fluidic connection 22d of the capsule 3 to be sealed since the portion of the circuit 20 concerned only "serves" the foam 23, which is at the extreme downstream of the circuit 20 and which is by default in communication with the atmosphere. Due to the one-way direction of circuit 20, any contamination of this portion would have no impact on the first portion (containing the sensor 24 to be preserved from contamination) between the sampling means 25 and the first connector 22b.
    In a particularly preferred manner, the capsule 3 has a substantially cylindrical shape relative to a given axis (vertical axis in the figures), with said tube and needle forming first fluidic connections 22a, 22b coinciding with said axis.
    The capsule thus engages with the case 2 in a translational movement along said axis and / or in rotation about said axis. The reverse movement disengages the capsule 3.
    In other words, the engagement movement is either an axial translation followed by a locking rotation, or a helical movement ("screwing" of the capsule 3 into the cavity C).
    In all cases, the engagement of the capsule 3 with the case 2 causes a pure translation of the needle along its axis, and therefore its insertion into the tube.
    Guide grooves can be provided to facilitate the engagement or disengagement movement. Deformable lugs can ensure locking when the capsule 3 is in place. It will be enough to force slightly in the other direction to deform the lugs and disengage the capsule 3.
    Due to the small size of the capsule 3, this manipulation is advantageously carried out by means of a tool 4, called "key", cooperating with the capsule 3. For this, the key has for example lugs 41b cooperating with cavities 41a of the capsule so as to temporarily fix the key 4 on the capsule 3 to transmit the movement of translation and / or rotation of engagement or disengagement.
    Preferably, the windows 26a and 26b respectively on the capsule 3 (in particular its side wall) and the housing 2 are configured so as to be aligned when the capsule 3 is engaged in the housing 2, so as to form said opening towards the exterior at the absorbent foam 23 allowing the evaporation of the stored interstitial liquid
    External capsule structure
    With particular reference to FIG. 2c and especially to FIG. 3, the capsule 3 preferably has a "sandwich" structure with, in order:
    - a first seal 30 between the capsule and the housing 2;
    - the sensor (s) 24 in the form of a micro-circuit having the contacts 12b;
    - A first structural element 31a supporting the sensor 24 and forming the lateral surface of the capsule 3 (as such it includes any grooves of engagement in the cavity C of the housing 2);
    - A second seal 32 for sealing between the first structural element 31 a and a second structural element 31b;
    - The first structural element 31b supporting the sampling means 25 and forming the lower surface (facing the skin) of the capsule 3. These sampling means 25 (as explained by micro-needles) are preferably easily removable in order to be able to independently replace capsule 3;
    a protruding ring 33 (typically a torus) made of a deformable material such as rubber around the transcutaneous sampling means 25, allowing when the device 1 and therefore the capsule is pressed against the skin to isolate a sterilized area of the skin ( it follows its outline) while limiting the risk of the means 25 sliding against the person's skin. This ring thus plays the role of non-slip and further limits contamination of the interstitial fluid.
    The capsule 3 advantageously has a movable part comprising said transcutaneous sampling means 25, relative to a fixed part (relative to the housing 2) of "body". The fixed part typically consists of the first structural element 31a, the sensor 24 and the connectors 12b, 22b, 22d, while the mobile part consists of the second structural element 31b with the means 25.
    The mobile part can allow the means 25 to remain in contact with the skin despite the movements of the case 2. It is very advantageous in combination with the ring 33: in the event of sudden movement by the user, the adhesion force of the ring 33 on the skin will be greater than the force necessary to move the movable part or the force to deform the skin (which is elastic). The means 25 will therefore not injure the user.
    Internal capsule structure
    With reference to FIGS. 4a and 4b, the circuit 20 has, in a particularly preferred embodiment, a spiral path between the structural elements 31a and 31b, which makes it possible to have the most fluid path possible and thus reduce resistance as much as possible. flow, while keeping a compact volume compatible with integration into a portable electronic device.
    This spiral path is either formed by a network of micro pipes, or by the shape of the first element 31a itself. The interstitial liquid sampled by the means 25 passes through the second element 31b to open at point 25 ’, it successively traverses the three electrodes of the sensor 24, before reaching the vertical tube forming the first connector 22b. A second parallel vertical tube forms the second connector 22d, through which the liquid returns to the capsule. As can be seen in FIG. 4b, the foam 23 is disposed opposite this second tube, in a radial passage of the element 31 leading to the window 26a through which the vapor of the liquid received by the foam 23 escapes .
    According to a second aspect, the invention relates to the capsule for the device 1 according to the first aspect as described above, ie for a device comprising in a box 2 data processing means 11 configured to process measurements acquired by a sensor 24 of a physical quantity of interstitial liquid, and a pump 21 of a one-way fluid circuit 20.
    The capsule 3 according to the second aspect is then characterized in that it comprises means for transcutaneous sampling 25 of interstitial liquid, said sensor 24, and an absorbent foam 23, arranged on the same fluid circuit 20 in one direction as the pump 21 (of the case 2 of the device 1), the capsule 3 being configured to engage with the case 2 in a removable manner.
    权利要求:
    Claims (14)
    [1]
    1. Device (1) for body monitoring, comprising a one-way fluid circuit (20) on which are arranged transcutaneous sampling means (25) of interstitial liquid, at least one sensor (24) of a physical quantity of liquid interstitial, absorbent foam (23) and pump (21), and data processing means (11) configured to process measurements acquired by said sensor (24) and control said pump (21);
    characterized in that it includes:
    a housing (2) in which the data processing means (11) and the pump (21) are arranged, and
    - a capsule (3) in which the sensor (24), the foam (23) and the transcutaneous sampling means (25) are arranged;
    the capsule (3) being configured to engage with the housing (2) removably.
    [2]
    2. Device according to claim 1, wherein the housing (2) and the capsule (3) comprise electrical connectors (12a, 12b) and fluid connectors (22a, 22b, 22c, 22d), configured so that when the capsule is engaged with the housing (2) said electrical connectors (12a, 12b) provide a connection between the data processing means (11) and the sensor (24), and said fluid connectors (22a, 22b, 22c, 22d) ensure that the fluid circuit (10) extends in a sealed manner both in the housing (2) and the capsule (3).
    [3]
    3. Device according to claim 2, wherein a first fluid connection (22a) of the housing (2) is a needle, and a first fluid connection (22b) of the capsule (3) is a tube having a cover pierced by said needle at the first engagement of the capsule (3) with the housing (2).
    [4]
    4. Device according to claim 3, wherein the capsule (3) has a substantially cylindrical shape relative to a given axis and engages with the housing (2) in a translational movement along said axis and / or rotation around of said axis by means of a tool (4), said tube and needle forming first fluidic connections (22a, 22b) coinciding with said axis so that the engagement of the capsule (3) with the housing (2) causes the insertion of the needle into the tube.
    [5]
    5. Device according to one of claims 1 to 4, wherein the capsule (3) has a movable part comprising said transcutaneous sampling means (25) intended to come into prolonged contact with the skin.
    [6]
    6. Device according to one of claims 1 to 5, wherein the capsule (3) comprises a protruding ring (33) of a deformable material around the transcutaneous sampling means (25).
    [7]
    7. Device according to one of claims 1 to 6, wherein the housing (2) has a user interface.
    [8]
    8. Device according to one of claims 1 to 7, comprising an opening (26a, 26b) to the outside at the level of the absorbent foam (23) allowing the evaporation of the stored interstitial liquid.
    [9]
    9. Device according to one of claims 1 to 8, wherein the transcutaneous sampling means (25) are micro-needles.
    [10]
    10. Device according to one of claims 1 to 9, in which the housing (2) comprises means for attaching to the reusable body, configured to keep the transcutaneous sampling means (25) in contact with the skin.
    [11]
    11. Device according to claim 10, wherein said
    5 reusable body attachment means consist of a strap or bracelet configured to surround a member.
    [12]
    12. Device according to one of claims 1 to 11, in which are successively arranged on the fluid circuit (20) the means of
    10 transcutaneous sample (25), the sensor (24), the pump (21) and the absorbent foam (23), so that the withdrawn liquid leaves the capsule (3) then returns there.
    [13]
    13. Capsule for a device according to one of claims 1
    [14]
    15 to 12, comprising the means for transcutaneous sampling (25) of interstitial liquid, the sensor (24), and the absorbent foam (23).
    3059 <
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    同族专利:
    公开号 | 公开日
    FR3059886B1|2021-04-09|
    WO2018104647A1|2018-06-14|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20050169799A1|2004-02-03|2005-08-04|Sysmex Corporation|Analyzer, cartridge, cartridge kit, and analyzing method|
    US20090131778A1|2006-03-28|2009-05-21|Jina Arvind N|Devices, systems, methods and tools for continuous glucose monitoring|
    WO2013132206A1|2012-03-06|2013-09-12|Swansea University|Biological fluid monitoring device|
    EP3603490A1|2018-08-03|2020-02-05|PKvitality|Metal/surface ratio of microneedle|
    EP3603512A1|2018-08-03|2020-02-05|PKvitality|Bi-rigidity adhesive patch|
    FR3084578A1|2018-08-03|2020-02-07|Pkvitality|SADDLE MANAGEMENT OF MICRO NEEDLES|
    EP3603508A1|2018-08-03|2020-02-05|PKvitality|Multi-position capsule|
    EP3603489A1|2018-08-03|2020-02-05|PKvitality|Body monitoring system with removable connection|
    FR3084777A1|2018-08-03|2020-02-07|Pkvitality|EXTERNAL BATTERY FOR PORTABLE MEMBER SYSTEM|
    EP3772332A1|2019-08-08|2021-02-10|PKvitality|Body monitoring system comprising a microneedle|
    EP3861934A1|2020-02-05|2021-08-11|PKvitality|Analyte measurement device comprinsing an adhesive patch|
    FR3108837A1|2020-04-06|2021-10-08|Pkvitality|ANALYTE MEASUREMENT DEVICE INCLUDING AN ADHESIVE PATCH|
    FR3109292A1|2020-04-16|2021-10-22|Pkvitality|Preparation of a needle sensor for a body monitoring system|
    法律状态:
    2017-12-13| PLFP| Fee payment|Year of fee payment: 2 |
    2018-06-15| PLSC| Publication of the preliminary search report|Effective date: 20180615 |
    2019-12-23| PLFP| Fee payment|Year of fee payment: 4 |
    2020-12-14| PLFP| Fee payment|Year of fee payment: 5 |
    2021-11-10| PLFP| Fee payment|Year of fee payment: 6 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1662200A|FR3059886B1|2016-12-09|2016-12-09|BODY SURVEILLANCE DEVICE|
    FR1662200|2016-12-09|FR1662200A| FR3059886B1|2016-12-09|2016-12-09|BODY SURVEILLANCE DEVICE|
    PCT/FR2017/053388| WO2018104647A1|2016-12-09|2017-12-05|Body monitoring device|
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